Hancinone possesses potentials on increasing the ability of HMC3 cells to phagocytosis of Aβ1-42 via TREM2/Syk/PI3K/AKT/mTOR signaling pathway
Hancinone could regulate the phenotype of HMC3 cells and promote cell phagocytosis of Aβ by modulating the TREM2/Syk/PI3K/AKT/mTOR signaling pathway. This systematic exploration indicates that hancinone has the therapeutic effect on AD.
Authors
- Guran Yu (ORCID: https://orcid.org/0000-0002-9356-8695)
- Hao Li (ORCID: https://orcid.org/0000-0002-9773-8313)
- Yong Zhou (ORCID: https://orcid.org/0000-0003-3309-2565)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
- Jiangsu Province Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1371/journal.pone.0324202
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China