Single-Cell Analysis Reveals Aspirin Restores Intervertebral Disc Integrity via Ferroptosis Regulation
The increased proportion of CDKN1A⁺aNPC cells serves as an early warning feature for the progression of IVDD. Aspirin stabilizes the targeting of GPX4, thereby inhibiting ferroptosis and exerting therapeutic effects on IVDD.
Authors
- Haiyun Niu
- Hao Qi (ORCID: https://orcid.org/0000-0003-0059-5377)
- Wang Zhang (ORCID: https://orcid.org/0000-0002-8636-2816)
- Ning Liu (ORCID: https://orcid.org/0000-0002-9487-9305)
- Hongyu Meng
- Peng Zhang (ORCID: https://orcid.org/0009-0004-7146-1805)
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/jir.s519218
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47