Unraveling the role of adjuvant chemotherapy in elderly triple-negative breast cancer: Insights from competing risk analysis using SEER data
Adjuvant chemotherapy significantly was associated with OCD, indirectly improving OS, but has limited direct impact on BCSD in elderly Patients with TNBC. Competing risk analysis highlights the importance of individualized treatment strategies. The validated nomogram provides a practical tool for precision medicine. Future research should explore biological mechanisms and validate these findings in multi-regional cohorts.
Authors
- Danwei Du
- Yangyang Xie (ORCID: https://orcid.org/0000-0002-6425-4347)
- Ziqiang Wang (ORCID: https://orcid.org/0000-0002-2874-1535)
- Rongguo Li (ORCID: https://orcid.org/0000-0001-7238-7863)
- Tingting Wang (ORCID: https://orcid.org/0000-0002-4912-7171)
- Xiaowen Li (ORCID: https://orcid.org/0000-0003-0894-9846)
Institutions
- Zhejiang Chinese Medical University (CN)
- Wenzhou Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- The First People's Hospital of Xiaoshan District, Hangzhou (CN)
Publication Details
- Journal
- Cancer Epidemiology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1016/j.canep.2025.102853
- Citations
- 1
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.94