Efficacy of linezolid in monotherapy q12h versus q8h versus combined with daptomycin in the treatment of experimental endocarditis caused by methicillin-resistant and glycopeptide-intermediate <i>Staphylococcus aureus</i> strains
Increasing linezolid to 600 mg/8 h might be useful as initial treatment in clinical practice. If required, the combination of daptomycin plus linezolid-q12h could be a suitable option in MRSA/GISA bacteraemia/endocarditis.
Authors
- Guillermina Fita
- María-Alexandra Cañas (ORCID: https://orcid.org/0000-0002-0521-7204)
- Merçè Brunet (ORCID: https://orcid.org/0000-0002-7154-916X)
- José Ortíz (ORCID: https://orcid.org/0000-0001-6341-4073)
- Climent Casals‐Pascual (ORCID: https://orcid.org/0000-0002-0867-8954)
- Bárbara Vidal (ORCID: https://orcid.org/0000-0003-4303-0851)
- Manel Almela
- Andrés Perissinotti (ORCID: https://orcid.org/0000-0003-4190-2425)
- María Alexandra Cañas
- Asunción Moreno (ORCID: https://orcid.org/0000-0002-5850-5007)
- Eduard Quintana (ORCID: https://orcid.org/0000-0002-5386-7463)
- Carlos Falces (ORCID: https://orcid.org/0000-0002-3483-3786)
- Juan M. Pericàs (ORCID: https://orcid.org/0000-0002-3645-3293)
- María Pilar Jiménez Sánchez (ORCID: https://orcid.org/0000-0002-2177-9389)
- Marta Sitges
- José Marı́a Tolosana (ORCID: https://orcid.org/0000-0002-1215-3472)
- Francesc Marco (ORCID: https://orcid.org/0000-0002-1863-6379)
- José María Miró (ORCID: https://orcid.org/0000-0001-8057-7755)
- Manuel Castellà (ORCID: https://orcid.org/0000-0001-9274-2121)
- Dolors Soy (ORCID: https://orcid.org/0000-0001-8128-345X)
- Jordi Vilà (ORCID: https://orcid.org/0000-0002-8025-3926)
- Daniel Pereda (ORCID: https://orcid.org/0000-0002-0526-8722)
- David Fuster (ORCID: https://orcid.org/0000-0003-0906-0627)
- Irene Rovira (ORCID: https://orcid.org/0000-0003-3415-027X)
- Elena Sandoval (ORCID: https://orcid.org/0000-0002-4242-5133)
- Pedro Castro (ORCID: https://orcid.org/0000-0002-6118-8970)
- Cristina García de la Mària (ORCID: https://orcid.org/0000-0002-0585-9469)
- José Ramírez
- Jaume Llopis
- Javier García‐González
- José L. Pomar
- José M Tolosana
- Marta Hernández-Meneses
- Manel Azqueta
- F Morales
Institutions
- Instituto de Salud Carlos III (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Hospital Clínic de Barcelona (ES)
- Barcelona Institute for Global Health (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1093/jac/dkaf149
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Economía y Competitividad
- Instituto de Salud Carlos III
- European Regional Development Fund
- Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona