Efficacy of linezolid in monotherapy q12h versus q8h versus combined with daptomycin in the treatment of experimental endocarditis caused by methicillin-resistant and glycopeptide-intermediate <i>Staphylococcus aureus</i> strains

Increasing linezolid to 600 mg/8 h might be useful as initial treatment in clinical practice. If required, the combination of daptomycin plus linezolid-q12h could be a suitable option in MRSA/GISA bacteraemia/endocarditis.

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Publication Details

Journal
Journal of Antimicrobial Chemotherapy
Published
2025-05-06
DOI
https://doi.org/10.1093/jac/dkaf149
Primary Topic
Antimicrobial Resistance in Staphylococcus
Type
article
Field-Weighted Citation Impact
0.00

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article

Efficacy of linezolid in monotherapy q12h versus q8h versus combined with daptomycin in the treatment of experimental endocarditis caused by methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus strains

Guillermina Fita, María-Alexandra Cañas, Merçè Brunet, José Ortíz et al.
Journal of Antimicrobial Chemotherapy
Antimicrobial Resistance in Staphylococcus
article

Efficacy of linezolid in monotherapy q12h versus q8h versus combined with daptomycin in the treatment of experimental endocarditis caused by methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus strains

Guillermina Fita, María-Alexandra Cañas, Merçè Brunet, José Ortíz, Climent Casals‐Pascual, Bárbara Vidal, Manel Almela, Andrés Perissinotti, María Alexandra Cañas, Asunción Moreno, Eduard Quintana, Carlos Falces, Juan M. Pericàs, María Pilar Jiménez Sánchez, Marta Sitges, José Marı́a Tolosana, Francesc Marco, José María Miró, Manuel Castellà, Dolors Soy, Jordi Vilà, Daniel Pereda, David Fuster, Irene Rovira, Elena Sandoval, Pedro Castro, Cristina García de la Mària, José Ramírez, Jaume Llopis, Javier García‐González, José L. Pomar, José M Tolosana, Marta Hernández-Meneses, Manel Azqueta, F Morales
article en

Abstract

Increasing linezolid to 600 mg/8 h might be useful as initial treatment in clinical practice. If required, the combination of daptomycin plus linezolid-q12h could be a suitable option in MRSA/GISA bacteraemia/endocarditis.

Journal of Antimicrobial ChemotherapyVol. 80(7)
Instituto de Salud Carlos III (ES), Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES), Hospital Clínic de Barcelona (ES), Barcelona Institute for Global Health (ES), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Universitat de Barcelona (ES)
Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, European Regional Development Fund, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona
Openalex Percentile: Top 85%
Antimicrobial Resistance in Staphylococcus
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