IGFBP5 promotes EndoMT and renal fibrosis through H3K18 lactylation in diabetic nephropathy
IGFBP5 promotes NLRP3 inflammasome-induced EndoMT and renal fibrosis by regulating glycolysis-mediated histone lactylation, accelerating the progression of DN. These findings provide a new potential therapeutic target for DN.
Authors
- Shaxi Ouyang (ORCID: https://orcid.org/0000-0003-2319-5640)
- Xiaofang Hu (ORCID: https://orcid.org/0000-0001-7766-4639)
- Wei Chen (ORCID: https://orcid.org/0000-0002-7614-4436)
- Ming Yang (ORCID: https://orcid.org/0000-0003-1698-0616)
- Mengwei Li (ORCID: https://orcid.org/0000-0001-6163-2827)
- Xiangyi Li (ORCID: https://orcid.org/0000-0001-8662-0865)
Institutions
- Hunan Normal University (CN)
- Zhuzhou Central Hospital (CN)
- Hunan Provincial People's Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1007/s00018-025-05718-5
- Citations
- 14
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 18.13
Funders
- Natural Science Foundation of Hunan Province