Alterations in ocular fungal microbiota in patients with fungal keratitis: a comparative study from coastal regions of Eastern China
Fungal keratitis significantly alters the ocular surface microbiome, which is characterized by decreased microbial richness and evenness. High-throughput sequencing revealed a complex interaction network with significant variability between healthy and infected eyes. Additionally, these findings suggest potential benefits from early and aggressive debridement in managing FK due to its impact on functional microbial groups.
Authors
- Yusen Huang (ORCID: https://orcid.org/0000-0001-5261-4950)
- Zhichao Ren (ORCID: https://orcid.org/0000-0002-1101-7823)
- Yanling Dong (ORCID: https://orcid.org/0000-0003-1460-1854)
- Qing Liu (ORCID: https://orcid.org/0000-0001-9534-3329)
- Wenfeng Li (ORCID: https://orcid.org/0000-0002-9166-8561)
- Xudong Zhao (ORCID: https://orcid.org/0000-0003-1493-3517)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shandong Eye Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- BMC Ophthalmology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1186/s12886-025-04133-5
- Citations
- 1
- Primary Topic
- Ocular Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- National Natural Science Foundation of China