Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma

The H3K27M mutation in diffuse midline glioma increases CD99 expression to suppress apoptosis, inhibit differentiation, and induce radioresistance, supporting using the anti-CD99 antibody 10D1 in pediatric brain cancer trials.

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Publication Details

Journal
Cancer Research
Published
2025-05-27
DOI
https://doi.org/10.1158/0008-5472.can-24-5027
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma

Rajeev Vibhakar, Breauna Brunt, Bridget Sanford, Ammu Suresh et al.
Cancer Research
Glioma Diagnosis and Treatment
article

Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma

Rajeev Vibhakar, Breauna Brunt, Bridget Sanford, Ammu Suresh, Krishna Madhavan, Senthilnath Lakshmanachetty, Ilango Balakrishnan, Sujatha Venkataraman, Adam L. Green, Etienne Danis, Angela Pierce, Siddhartha S. Mitra, Nathan Davidson, Nathan Dahl, John DeSisto, Faye Walker, Andrew M. Donson, Zachary James Nuss, Joshua Michlin, Dong Wang, Kenneth L. Jones
article en

Abstract

The H3K27M mutation in diffuse midline glioma increases CD99 expression to suppress apoptosis, inhibit differentiation, and induce radioresistance, supporting using the anti-CD99 antibody 10D1 in pediatric brain cancer trials.

Cancer ResearchVol. 85(16)
University of California, San Francisco (US), Sheridan College (US), Morgan Adams Foundation (US), ID Genomics (United States) (US), University of Colorado Cancer Center (US), University of Colorado Anschutz Medical Campus (US), University of Colorado Denver (US)
Good health and well-being
Openalex Percentile: Top 83%
Glioma Diagnosis and Treatment
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Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma — Rajeev Vibhakar, Breauna Brunt, et al. · Cancer Research (2025) | TGRS Research Map | TGRS