Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition
Targeting Tau N368 through immunotherapy alleviates tau-driven neurodegeneration, restores synaptic function, and improves accompanying Aβ pathology in AD models. Our results confirmed that Tau N368 is an exceptional biomarker and a promising therapeutic target, disrupting AD progression by addressing tau aggregation and its downstream effects.
Authors
- Jie Xiang (ORCID: https://orcid.org/0000-0003-3494-5072)
- Xi Ye (ORCID: https://orcid.org/0000-0002-1694-2786)
- Xia Liu (ORCID: https://orcid.org/0000-0002-2542-0322)
- Keqiang Ye (ORCID: https://orcid.org/0000-0002-7657-8154)
- Zhengjiang Qian (ORCID: https://orcid.org/0000-0003-1306-6829)
- Zhentao Zhang (ORCID: https://orcid.org/0000-0001-6708-1472)
- Zhi-Hao Wang (ORCID: https://orcid.org/0000-0002-2517-8679)
- Shengxi Wu (ORCID: https://orcid.org/0000-0002-3210-9567)
- Guangxing Wang (ORCID: https://orcid.org/0000-0003-0316-592X)
- Ying Rao Wei
Institutions
- University of Electronic Science and Technology of China (CN)
- Emory University (US)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Shenzhen University Health Science Center (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1186/s13024-025-00854-9
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Research Fund for Young Star of Science and Technology in Shaanxi Province
- National Natural Science Foundation of China
- Young Talent Support Program of Shaanxi Province University
- Shenzhen Research and Development Program
- Postdoctoral Research Foundation of China
- National Postdoctoral Program for Innovative Talents
- Shaanxi Key Science and Technology Innovation Team Project
- Basic and Applied Basic Research Foundation of Guangdong Province