The impact of VUS reclassification on reproductive decision making
The rate of conflicting reporting of a VUS has increased in 3 years and is currently at 4.8%. A potential upgrade of a VUS to pathogenic or likely pathogenic may turn the variant "actionable," justifying testing embryos for the variant through PGT-M.
Authors
- Avner Hershlag
- Kenan Onel (ORCID: https://orcid.org/0000-0002-2021-6250)
- Alexandra Peyser (ORCID: https://orcid.org/0000-0001-7516-9810)
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- North Shore University Hospital (US)
- Stony Brook University Hospital (US)
- Stony Brook School (US)
- North Shore Diabetes and Endocrine Associates (US)
- Cooper Union (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1371/journal.pone.0308771
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00