Germline genomic profiling of patients with early-onset colorectal cancer
While most EO-CRC cases are sporadic, approximately one-fifth arises within the context of hereditary cancer predisposition syndromes. As <i>FLCN</i> and <i>SDH</i> are not currently included in the current guidelines for EO-CRC, PVs/LPVs in these genes may be underestimated. To better understand their significance, we recommend including their assessment in all patients with EO-CRC.
Authors
- Silvia Ghezzi (ORCID: https://orcid.org/0000-0002-7586-663X)
- Laura Monti (ORCID: https://orcid.org/0000-0002-1856-0036)
- Monica Ronzoni (ORCID: https://orcid.org/0000-0002-2845-275X)
- Gianluca Mauri (ORCID: https://orcid.org/0000-0002-7646-0973)
- Andrea Sartore‐Bianchi (ORCID: https://orcid.org/0000-0003-0780-0409)
- Salvatore Siena (ORCID: https://orcid.org/0000-0002-2681-2846)
- Roberto Rosati (ORCID: https://orcid.org/0000-0002-0475-3654)
- F. Gaudioso (ORCID: https://orcid.org/0000-0001-8071-3796)
- Valentina Burgio (ORCID: https://orcid.org/0000-0002-0146-4136)
- Alessandro Mannucci (ORCID: https://orcid.org/0000-0002-1655-6762)
- Lorena Mosca (ORCID: https://orcid.org/0000-0002-6767-2368)
- S. Mariano
- H. Mittal
- Ugo Cavallari (ORCID: https://orcid.org/0000-0002-3395-4033)
- Marta Puzzono (ORCID: https://orcid.org/0000-0001-9959-9604)
- G.M. Cavestro
Institutions
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- ESMO Gastrointestinal Oncology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1016/j.esmogo.2025.100182
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Seagen
- Associazione Italiana per la Ricerca sul Cancro
- Regione Lombardia