A multi-omics integration approach relying on circulating factors does not discern subtypes of childhood type 1 diabetes
These findings challenge the assumption that T1D heterogeneity reflects diverse developmental mechanisms. These results add to the ongoing debate on endotypes and carry important implications for clinical trial design-particularly in how treatments are evaluated for their effectiveness across broad and diverse patient populations.
Authors
- Lorenzo Piemonti (ORCID: https://orcid.org/0000-0002-2172-2198)
- Marco J. Morelli (ORCID: https://orcid.org/0000-0003-1862-667X)
- Valentina Codazzi (ORCID: https://orcid.org/0009-0000-7489-4439)
- Giulia Maria Scotti (ORCID: https://orcid.org/0000-0002-6929-4858)
- Paolo Fiorina (ORCID: https://orcid.org/0000-0002-1093-7724)
- Debora Carnovale
- Alessandra Mandelli (ORCID: https://orcid.org/0000-0002-6494-7776)
- Camillo Bechi Genzano (ORCID: https://orcid.org/0000-0003-2533-9329)
- Andrea Giustina (ORCID: https://orcid.org/0000-0001-6783-3398)
- Andrea Rigamonti (ORCID: https://orcid.org/0000-0003-2557-4150)
- Vito Lampasona (ORCID: https://orcid.org/0000-0001-5162-8445)
- Alessandra Petrelli (ORCID: https://orcid.org/0000-0002-5639-9415)
- Ilaria Marzinotto (ORCID: https://orcid.org/0000-0002-4765-4509)
- Riccardo Bonfanti (ORCID: https://orcid.org/0000-0002-4104-2763)
- Eugenia Bezzecchi (ORCID: https://orcid.org/0000-0002-8838-4736)
- Anna Giovenzana (ORCID: https://orcid.org/0000-0002-3889-456X)
- Giulio Frontino (ORCID: https://orcid.org/0000-0002-6115-2476)
- Manuela Battaglia (ORCID: https://orcid.org/0000-0003-4535-3152)
- Nicola Baldoni
Institutions
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1038/s43856-025-00922-7
- Citations
- 2
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.63