A probabilistic approach to visualize the effect of missing data on PCA in ancient human genomics
Our results emphasize the importance of accounting for projection uncertainty in ancient population studies. We therefore make our probabilistic model available through TrustPCA, a user-friendly web tool that provides researchers with uncertainty estimates alongside PCA projections, facilitating data exploration in ancient human genomic studies and enhancing transparency in data quality reporting.
Authors
- Susanne Zabel (ORCID: https://orcid.org/0000-0003-3374-149X)
- Cosimo Posth (ORCID: https://orcid.org/0000-0002-8206-3907)
- Kay Nieselt (ORCID: https://orcid.org/0000-0002-1283-7065)
- Samira Breitling
Institutions
- Senckenberg Centre for Human Evolution and Palaeoenvironment (DE)
- Department of Archaeology (LK)
- University of Tübingen (DE)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1186/s12864-025-11728-1
- Citations
- 1
- Primary Topic
- Forensic and Genetic Research
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Eberhard Karls Universität Tübingen