Protopanaxadiol induces apoptosis through JNK signaling pathway and targeting MLK3 in human melanoma
Our findings revealed that PPD exerts potent anti-melanoma effects by directly targeting MLK3 and activating the MLK3-JNK signaling pathway, leading to apoptosis. These results provide novel insights into the molecular mechanism of PPD and suggest its potential as a therapeutic agent for melanoma treatment.
Authors
- Jae Youl Cho (ORCID: https://orcid.org/0000-0001-8141-9927)
- Ziliang He
- Dae‐Won Kim (ORCID: https://orcid.org/0000-0001-7792-0583)
Institutions
- Sungkyunkwan University (KR)
- Dankook University (KR)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1016/j.jgr.2025.05.008
- Citations
- 1
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Dankook University