Implication of the Dose of Mineralocorticoid Receptor Antagonist Following Transcatheter Edge-to-Edge Mitral Valve Repair
In older patients who underwent TEER for secondary mitral regurgitation caused by systolic heart failure, even a low-dose MRA was associated with improved clinical outcomes compared with no MRA administration. However, further up-titration of the MRA dose did not result in additional improvements in clinical outcomes. (OCEAN-Mitral registry; UMIN000023653).
Authors
- Yuki Izumi (ORCID: https://orcid.org/0000-0003-3004-906X)
- Mike Saji (ORCID: https://orcid.org/0000-0003-2057-109X)
- Teruhiko Imamura (ORCID: https://orcid.org/0000-0002-7294-7637)
- Masahiko Asami (ORCID: https://orcid.org/0000-0002-2102-033X)
- Yohei Ohno (ORCID: https://orcid.org/0000-0003-4203-7613)
- Hiroki Bota
- Yusuke Watanabe (ORCID: https://orcid.org/0000-0003-2297-5303)
- Nobuyuki Fukuda
- Masanori Yamamoto (ORCID: https://orcid.org/0000-0001-5210-6382)
- Koichiro Kinugawa (ORCID: https://orcid.org/0000-0003-0009-8477)
- Hiroshi Ueno (ORCID: https://orcid.org/0000-0003-0360-5761)
- Kentaro Hayashida (ORCID: https://orcid.org/0000-0002-1750-1982)
- Toshiaki Otsuka (ORCID: https://orcid.org/0009-0004-7994-7594)
- Junichi Yamaguchi (ORCID: https://orcid.org/0000-0003-0967-0978)
- Yusuke Enta (ORCID: https://orcid.org/0000-0003-1931-1012)
- Shunsuke Kubo (ORCID: https://orcid.org/0000-0003-4794-7843)
- Kazuki Mizutani (ORCID: https://orcid.org/0000-0001-7206-4538)
- Makoto Amaki (ORCID: https://orcid.org/0000-0001-5132-5129)
- Daisuke Hachinohe (ORCID: https://orcid.org/0000-0003-4828-1836)
- Masaki Izumo (ORCID: https://orcid.org/0000-0001-8597-1479)
- Masahiro Yamawaki (ORCID: https://orcid.org/0000-0003-4334-2441)
- Toru Naganuma (ORCID: https://orcid.org/0000-0002-4864-8805)
- Shuhei Tanaka (ORCID: https://orcid.org/0000-0001-7551-3431)
- Shinichi Shirai
- Shingo Mizuno (ORCID: https://orcid.org/0009-0009-6030-2418)
- Kazuhisa Kodama (ORCID: https://orcid.org/0000-0002-4310-8906)
Institutions
- Tokai University (JP)
- St. Marianna University School of Medicine (JP)
- Keio University (JP)
- Toyama College (JP)
- Kurashiki Central Hospital (JP)
- Sapporo Higashi Tokushukai Hospital (JP)
- New Tokyo Hospital (JP)
- Saiseikai Kumamoto Hospital (JP)
- Sapporo Science Center (JP)
- National Cerebral and Cardiovascular Center (JP)
- Toyohashi Heart Center (JP)
- Sakakibara Hospital (JP)
- Mitsui Memorial Hospital (JP)
- Tokyo Women's Medical University (JP)
- Shonan Kamakura General Hospital (JP)
- Saiseikai Yokohama Eastern Hospital (JP)
- Kokura Memorial Hospital (JP)
- University of Toyama (JP)
- Nippon Medical School (JP)
- Teikyo University (JP)
- Kindai University (JP)
Publication Details
- Journal
- JACC Asia
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1016/j.jacasi.2025.03.014
- Citations
- 4
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.55