OCT4 and MENA immunoprofiling in salivary mucoepidermoid carcinoma

The differential expression patterns of OCT4 and MENA in MEC prognosticate distinct regulatory mechanisms. While OCT4 cytoplasmic expression may presage early involvement in carcinogenesis, MENA cellular expression portends potentially independent molecular pathways, possibly encompassing subnetworks in the Wnt/β-catenin and TGF-β signaling cascades. MENA may serve as a biomarker for predicting the aggressive behavior of MEC.

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Publication Details

Journal
Diagnostic Pathology
Published
2025-05-27
DOI
https://doi.org/10.1186/s13000-025-01665-8
Primary Topic
Salivary Gland Tumors Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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OCT
article

OCT4 and MENA immunoprofiling in salivary mucoepidermoid carcinoma

Khadiga M. Ali, Doaa A. Farag, Lawahez El. M. Ismail, Omnia Samir
Diagnostic Pathology
Salivary Gland Tumors Diagnosis and Treatment
article

OCT4 and MENA immunoprofiling in salivary mucoepidermoid carcinoma

Khadiga M. Ali, Doaa A. Farag, Lawahez El. M. Ismail, Omnia Samir
article en

Abstract

The differential expression patterns of OCT4 and MENA in MEC prognosticate distinct regulatory mechanisms. While OCT4 cytoplasmic expression may presage early involvement in carcinogenesis, MENA cellular expression portends potentially independent molecular pathways, possibly encompassing subnetworks in the Wnt/β-catenin and TGF-β signaling cascades. MENA may serve as a biomarker for predicting the aggressive behavior of MEC.

Diagnostic PathologyVol. 20(1)
Mansoura University (EG)
Science and Technology Development Fund, Mansoura University
Good health and well-being
Openalex Percentile: Top 79%
Salivary Gland Tumors Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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OCT4 and MENA immunoprofiling in salivary mucoepidermoid carcinoma — Khadiga M. Ali, Doaa A. Farag, et al. · Diagnostic Pathology (2025) | TGRS Research Map | TGRS