Biocide exposure in extended-spectrum <i>β</i>-lactamase-producing <i>Klebsiella pneumoniae</i>: effect on increased biocide and antibiotic MICs, genetic changes, and fitness cost
Biocide exposure in ESBL-Kp is associated with (i) acquisition of biocide and antibiotic co-resistance, (ii) emergence of mutations in genes involved in co-resistance, and those related to relevant biological processes, (iii) upregulation of acrB and downregulation of ompK35 and ompK36, and (iv) no significant fitness cost.
Authors
- Manuel Alcalde‐Rico (ORCID: https://orcid.org/0000-0002-1987-4600)
- Patricia Pérez‐Palacios (ORCID: https://orcid.org/0000-0002-3775-5330)
- Álvaro Pascual (ORCID: https://orcid.org/0000-0002-8672-5891)
- Jesús Rodríguez‐Baño (ORCID: https://orcid.org/0000-0001-6732-9001)
- Francisco Javier Caballero-Moyano
- Felipe Fernández-Cuenca (ORCID: https://orcid.org/0000-0002-6597-6130)
Institutions
- Instituto de Salud Carlos III (ES)
- Hospital Universitario Virgen Macarena (ES)
- Instituto de Biomedicina de Sevilla (ES)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1093/jambio/lxaf121
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00