Mechanical and biological properties of 3D-printed porous titanium scaffolds coated with composite growth factors
Radial-gradient porous scaffolds exhibit compatible elastic modulus, excellent cell compatibility, and osteogenic potential, making them promising candidates for bone tissue engineering applications in dentistry. Furthermore, the composite scaffolds incorporating BMP-2 and PDGF-BB-loaded chitosan microspheres demonstrated enhanced osteogenic differentiation compared to single-factor modified porous scaffolds, providing experimental evidence for the clinical application of novel implants.
Authors
- G. H. Gong (ORCID: https://orcid.org/0000-0001-7192-1833)
- Hongbin Dai (ORCID: https://orcid.org/0000-0002-8168-5878)
- Shan Xiao (ORCID: https://orcid.org/0000-0002-3667-7262)
- Diansheng Chen (ORCID: https://orcid.org/0000-0003-4599-876X)
- Shuqing Song (ORCID: https://orcid.org/0000-0002-3514-3760)
- Qing Zou (ORCID: https://orcid.org/0000-0002-2729-2491)
- Chongxue Wu
- Shengxiang Zhang (ORCID: https://orcid.org/0000-0001-6524-9673)
- Bing Wen (ORCID: https://orcid.org/0000-0001-8141-6662)
- Jianping Li (ORCID: https://orcid.org/0000-0003-0625-1575)
- Chunwen Jiang
Institutions
- Jiujiang University (CN)
- Nanchang University (CN)
- Shanghai Stomatological Hospital (CN)
- Pudong Medical Center (CN)
- Xiamen Chang Gung Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1186/s12903-025-06110-2
- Citations
- 6
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 4.04
Funders
- National Natural Science Foundation of China
- Nanchang University