Cu(I)-catalysed chemo-, regio-, and stereoselective radical 1,2-carboalkynylation with two different terminal alkynes
Transition-metal-catalysed asymmetric multicomponent reactions with two similar substrates often suffer from the lack of strategies to control the chemo-, regio-, and stereoselectivity of these substrates due to the close similarity in the chemical structures and properties of each reagent. Here, we describe a Cu(I)-catalysed asymmetric radical 1,2-carboalkynylation of two different terminal alkynes and alkyl halides with high chemo-, regio-, and stereoselectivity by using sterically bulky chiral tridentate anionic N,N,P-ligands and modulating alkynes with different electronic properties to circumvent above-mentioned challenges. This method features good substrate scope, high functional group tolerance of two different terminal alkynes, and diverse alkyl halides, providing universal access to a series of useful axially chiral 1,3-enyne building blocks.
Authors
- Jun-Bin Tang (ORCID: https://orcid.org/0009-0006-7542-6462)
- Zhong‐Liang Li (ORCID: https://orcid.org/0000-0002-2043-5701)
- Yong‐Feng Cheng (ORCID: https://orcid.org/0000-0001-6868-0848)
- Song Qiao (ORCID: https://orcid.org/0000-0002-8590-0926)
- Liwen Fan (ORCID: https://orcid.org/0000-0001-8168-2928)
- Jun-Qian Bian
- Qiang‐Shuai Gu (ORCID: https://orcid.org/0000-0002-3840-425X)
- Jiajia Fu (ORCID: https://orcid.org/0009-0003-0436-3116)
- Qin Li
- Yufeng Zhang (ORCID: https://orcid.org/0000-0002-1194-669X)
- Xin‐Yuan Liu (ORCID: https://orcid.org/0000-0002-6978-6465)
- Peng Yu (ORCID: https://orcid.org/0000-0003-1089-6421)
- Pengfei Wang (ORCID: https://orcid.org/0000-0002-8233-8798)
Institutions
- Dongguan University of Technology (CN)
- Southern University of Science and Technology (CN)
- Centre of Excellence for Advanced Materials (CN)
- Institute for Advanced Study (DE)
Publication Details
- Journal
- Nature Communications
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1038/s41467-025-60012-z
- Citations
- 6
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- National Natural Science Foundation of China
- Southern University of Science and Technology