Circulating tumor DNA in ALK-positive anaplastic large cell lymphoma: a proof-of-concept study
In this multicenter study, we were able to detect circulating tumor DNA (ctDNA) in 87.5% of patients with the rare disease ALK + ALCL. Moreover, by analyzing ctDNA from samples collected at disease progression, we were able to identify resistance mutations to ALK inhibitors. Furthermore, ctDNA proved to be a valuable and consistent tool for monitoring minimal residual disease.
Authors
- Laurence Brugières (ORCID: https://orcid.org/0000-0002-7798-6651)
- Ludovic Lacroix (ORCID: https://orcid.org/0000-0003-2535-1010)
- Francesco Facchinetti (ORCID: https://orcid.org/0000-0001-6313-6341)
- Laurence Lamant (ORCID: https://orcid.org/0000-0002-1123-7658)
- Luc Friboulet (ORCID: https://orcid.org/0000-0002-1129-4978)
- Floriane Brayé (ORCID: https://orcid.org/0009-0002-3527-6771)
- Damien Vasseur (ORCID: https://orcid.org/0000-0001-8787-1498)
- Charlotte Rigaud (ORCID: https://orcid.org/0000-0002-1774-778X)
- Noémie Pata-Merci
- Samuel Abbou (ORCID: https://orcid.org/0000-0002-7159-8869)
- David Sibon (ORCID: https://orcid.org/0000-0002-9205-625X)
- Marc Deloger (ORCID: https://orcid.org/0000-0002-6352-101X)
- Étienne Rouleau (ORCID: https://orcid.org/0000-0002-9046-257X)
- Véronique Minard-Colin
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut universitaire du cancer de Toulouse Oncopole (FR)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Dana-Farber Cancer Institute (US)
- Laboratoire d'études sur les monothéismes (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
Publication Details
- Journal
- npj Precision Oncology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1038/s41698-025-00944-3
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00