Early-stage mycosis fungoides: searching for biomarkers associated with advanced-stage progression
This study shows that the microenvironment and probably the phenotype of neoplastic T cells of early-stage mycosis fungoides (MF) samples from patients with MF who suffered progression or remained stable are different. Moreover, we propose that the overexpression of CD30, CXCL13 and BIRC3 in early-stage MF is related to progression. Further spatial transcriptomic studies or single-cell analysis in further case series are needed to corroborate our findings.
Authors
- Raquel Pajares
- Fina Climent (ORCID: https://orcid.org/0000-0002-4360-8388)
- Ruth Alonso‐Alonso (ORCID: https://orcid.org/0000-0001-9503-7268)
- Socorro Marıá Rodríguez-Pinilla (ORCID: https://orcid.org/0000-0002-2191-1327)
- Ignacio Torres‐Navarro (ORCID: https://orcid.org/0000-0002-5448-5360)
- Carlos Moreno‐Vílchez (ORCID: https://orcid.org/0000-0003-1157-2162)
- Pablo Luis Ortiz-Romero (ORCID: https://orcid.org/0000-0003-2985-9639)
- Daniel Martıń-Torregrosa (ORCID: https://orcid.org/0009-0008-7918-4733)
- Carmen Herencia
- Jennifer Borregón
- Raquel Rivera (ORCID: https://orcid.org/0000-0002-4604-0724)
- Cristina Muniesa Montserrat (ORCID: https://orcid.org/0000-0002-0703-943X)
- Jesús Frutos Dıáz-Alejo (ORCID: https://orcid.org/0000-0001-8673-3165)
- Marta Rodríguez (ORCID: https://orcid.org/0000-0001-8543-6767)
- Marcos Rebollo-González (ORCID: https://orcid.org/0000-0003-1242-6669)
- Francisco Javier Dıáz de la Pinta (ORCID: https://orcid.org/0000-0002-7070-0550)
- Vanessa Gargallo‐Moneva
- Rebeca Manso (ORCID: https://orcid.org/0000-0002-5450-4146)
- José Luis Rodríguez‐Peralto (ORCID: https://orcid.org/0000-0002-6578-7153)
- Octavio Servitje (ORCID: https://orcid.org/0000-0002-9910-9617)
- Juan Torre‐Castro (ORCID: https://orcid.org/0000-0003-0444-7419)
- Alfonso Gotor‐Rivera (ORCID: https://orcid.org/0009-0005-9063-8554)
- Daniel Morillo-Giles
- Alicia Sánchez-Martínez
- Marıá Moreno-Delgado
Institutions
- Universidad Complutense de Madrid (ES)
- Bellvitge University Hospital (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Hospital Universitario 12 De Octubre (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Instituto de Investigación Sanitaria La Fe (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1093/bjd/ljaf204
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00