Aspergillicin I, new depsipeptide from the marine-derived fungal strain <i>Aspergillus uvarum</i> BTBU20212048

A new depsipeptide, aspergillicin I (<b>1</b>), along with ten known compounds, aspergillicin A (<b>2</b>), asterric acid (<b>3</b>), methyl asterric acid (<b>4</b>), sulochrin (<b>5</b>), monomethylsulochrin (<b>6</b>), aloe emodin (<b>7</b>), citreorosein (<b>8</b>), questinol (<b>9</b>), 3-methylemodin (<b>10</b>), and RF-3192C (<b>11</b>), were identified from the solid culture of marine-derived fungal <i>Aspergillus uvarum</i> BTBU20212048 which was isolated from a marine mud sample. The chemical structures of the isolated compounds were determined by 1D, 2D NMR and high-resolution electrospray ionisation mass spectrometry (HRESIMS) analysis. Compounds <b>7</b> and <b>10</b> exhibited inhibitory effect against gram-positive pathogen of <i>S. aureus</i> with minimum inhibitory concentrations of 12.5 and 3.125 μg/mL, respectively.