Synthesis of Dibenzopyranones via Visible Light‐Mediated Pd‐Catalyzed Esterification/C─H Activation Cascade
Abstract Dibenzopyranone is a privileged structure in natural products that exhibits multiple fascinating properties. Reported herein, is the synthesis of dibenzopyranone from o ‐bromo benzoic acids and aryl formates. The combination of a Pd‐catalyst and light irradiation allows the reaction to proceed under mild conditions at room temperature. Preliminary mechanistic studies suggested that the reaction undergoes an esterification process followed by a cyclization to form the dibenzopyranone ring structure. This method provides a complementary approach for the synthesis of substituted benzo[ c ]chromen‐6‐one from readily available materials.
Authors
- Aurapat Ngamnithiporn (ORCID: https://orcid.org/0000-0002-5389-8171)
- Padon Chuentragool (ORCID: https://orcid.org/0000-0002-7466-8455)
- Somsak Ruchirawat (ORCID: https://orcid.org/0000-0001-5842-4330)
- Teesuda Sirichai
Institutions
- Chulabhorn Graduate Institute (TH)
- Chulabhorn Research Institute (TH)
- Office of the Higher Education Commission (TH)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1002/ajoc.202500246
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Thailand Toray Science Foundation
- National Research Council of Thailand
- Chulabhorn Research Institute
- Ministry of Higher Education, Science, Research and Innovation, Thailand
- Thailand Science Research and Innovation
- Toray Science Foundation