Synthetic Studies toward 4,9-Anhydro-10-hemiketal-5-deoxy-tetrodotoxin, a Proposed Biosynthetic Precursor of Tetrodotoxin
Abstract We report the synthesis of the 8-epi analogue of 4,9-anhydro-10-hemiketal-5-deoxytetrodotoxin, a proposed biosynthetic precursor of tetrodotoxin isolated from the Japanese toxic newt Cynops ensicauda popei, from a previously reported protected amine via stereoselective hydroxylation of the bicyclic carbocycle.
Authors
- Yuta Kudo (ORCID: https://orcid.org/0000-0002-1586-2004)
- Toshio Nishikawa (ORCID: https://orcid.org/0000-0003-1955-6618)
- Mari Yotsu‐Yamashita (ORCID: https://orcid.org/0000-0002-5009-0409)
- Tadachika Miyasaka (ORCID: https://orcid.org/0000-0003-3143-4576)
- Masaatsu Adachi (ORCID: https://orcid.org/0000-0001-7615-3861)
Institutions
- Tohoku University (JP)
- Nagoya University (JP)
Publication Details
- Journal
- Synlett
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1055/s-0043-1773544
- Citations
- 1
- Primary Topic
- Marine Toxins and Detection Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- Japan Society for the Promotion of Science