Ciliary IFT88 inhibits intervertebral disc degeneration under excessive mechanical stress by regulating endplate cartilage calcification
Our study demonstrates that IFT88 inhibits TRPV4, thereby protecting endplate cartilage and positioning IFT88 as a promising therapeutic target for IDD and endplate calcification.
Authors
- Libo Jiang (ORCID: https://orcid.org/0000-0002-5082-1849)
- Zhirui Dong (ORCID: https://orcid.org/0009-0006-1235-6559)
- Wang Ding (ORCID: https://orcid.org/0000-0003-2138-1634)
- Yu-Kai Huang (ORCID: https://orcid.org/0000-0001-5377-1405)
- Wenxian Wang (ORCID: https://orcid.org/0000-0002-3047-4149)
- Zhiyang Gao
- Hua He (ORCID: https://orcid.org/0000-0002-7784-3036)
- Ming-Dong Zhao
- Yuxiang Ge (ORCID: https://orcid.org/0000-0002-4292-9905)
- Jing Wang
- Guang-Cheng Yuan
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Jinshan Hospital of Fudan University (CN)
- Minhang District Central Hospital (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1016/j.jare.2025.05.042
- Citations
- 3
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.41