Disruption of Plexin-A1 signaling by FTX-101: mode of action and effect on oligodendrocyte biology
FTX-101 enhanced the recruitment of oligodendrocytes and promoted myelination, addressing critical medical needs in demyelinating conditions. Specificity, solubility in water, and enduring stability render FTX-101 a highly promising candidate for a first-in-class therapeutic agent.
Authors
- Michaël van der Heyden
- Dominique Bagnard (ORCID: https://orcid.org/0000-0002-5261-902X)
- Oliver A. Kent (ORCID: https://orcid.org/0000-0001-6494-4383)
- Violetta Dimitriadou
- Caroline Spenlé (ORCID: https://orcid.org/0000-0002-6353-3109)
- Fabien Binamé (ORCID: https://orcid.org/0000-0002-9758-1512)
- Kévin Leguay (ORCID: https://orcid.org/0000-0002-5691-4157)
- Joseph A. Mancini
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- HTC (Taiwan) (TW)
- FPInnovations (CA)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1016/j.biopha.2025.118186
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00