Sp2 Transcription Factor Alleviates Chondrocyte Loss in Osteoarthritis by Repressing the DVL1‐Dependent Wnt/β‐Catenin Signaling Pathway
This study demonstrates that SP2 represses DVL1 transcription and inactivates the Wnt/β-catenin signaling, thus alleviating chondrocyte loss and cartilage injury in OA mice.
Authors
- Yue Wang (ORCID: https://orcid.org/0000-0003-0364-885X)
- Lin Yuan (ORCID: https://orcid.org/0000-0003-2065-2666)
- Xiaolei Chen
- Xinpeng Zheng
Institutions
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- The Journal of Gene Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/jgm.70021
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.34