Formation of Colchicine‐incorporated Hybrid Nanoflower With an Intrinsic Peroxidase‐Mimic and Enhanced Antimicrobial Activities
We report the formation of colchicine-Cu<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> hybrid nanoflowers (Colc-NFs) with intrinsic catalytic and antimicrobial activities with and without hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). While the colchicine molecule, known as a secondary metabolite with anti-inflammatory properties, was used as an organic part of Colc-NFs, the Cu<sup>2+</sup> ion acted as an inorganic part of Colc-NFs. The acetamide group in the colchicine structure may react with Cu<sup>2+</sup> ions in phosphate-buffered saline to form Colc-NFs. The Colc-NFs exhibited both an intrinsic peroxidase-mimic activity against guaiacol and antimicrobial activities against Escherichia coli, Staphylococcus aureus, and Candida albicans in the presence of H<sub>2</sub>O<sub>2</sub>. Both activities of the Colc-NFs rely on a Fenton-like reaction mechanism by producing reactive hydroxyl radicals. In addition to that high surface-to-volume ratio and porous structure of Colc-NFs may contribute to their peroxidase-mimic activities depending on the Fenton-like reaction.
Authors
- İsmail Öçsoy (ORCID: https://orcid.org/0000-0002-5991-3934)
- İzzet Burçin Satıcıoğlu (ORCID: https://orcid.org/0000-0002-2721-3204)
- Fatih Doğan Koca (ORCID: https://orcid.org/0000-0001-9774-3019)
- Betül Özen (ORCID: https://orcid.org/0000-0003-0499-3524)
- Erdal Yılmaz (ORCID: https://orcid.org/0000-0001-6348-3618)
- Dilek Demirezen Yılmaz
- Mustafa Nisari
Institutions
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
- Nuh Naci Yazgan University (TR)
- Erciyes University (TR)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1002/cbdv.202500911
- Citations
- 1
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.52