[RGL1 overexpression promotes metastasis of colorectal cancer by upregulating motile focal adhesion assembly <i>via</i> activating the CDC42/RAC1 complex].
RGL1 is highly expressed in metastatic CRC and promotes distant metastasis of CRC by activating the CDC42/RAC1 complex to facilitate the formation of motile focal adhesions. These findings suggest that RGL1 can potentially serve as a therapeutic target for CRC metastasis.
Authors
- Li Weng (ORCID: https://orcid.org/0009-0000-6080-7488)
- Na Weng
- Bin Tan (ORCID: https://orcid.org/0000-0002-4248-9460)
- Kehong Zheng (ORCID: https://orcid.org/0000-0002-6773-8275)
- Jiayu Gu (ORCID: https://orcid.org/0000-0002-4840-7251)
- Wentao Zeng
Institutions
- Zhujiang Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-05-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.05.16
- Primary Topic
- Connective tissue disorders research
- Type
- article