[Circ_EPHB4 regulates temozolomide sensitivity in glioma cells through the miR-424-5p/Wnt3 axis].
Circ_EPHB4 regulates Wnt3 expression through "sponge adsorption" of miR-424-5p, thereby modulating TMZ-resistant glioblastoma cell clonogenesis, apoptosis, and TMZ sensitivity, suggesting the potential of circ_EPHB4 as a therapeutic target for reversing drug resistance of gliomas.
Authors
- Jin Chen (ORCID: https://orcid.org/0000-0003-4757-512X)
- Bo Liu (ORCID: https://orcid.org/0000-0002-0459-9132)
- Jingping Liu (ORCID: https://orcid.org/0000-0003-3242-9904)
- Xiyun Fei
- Yuxiang Liao
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-05-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.05.06
- Primary Topic
- Circular RNAs in diseases
- Type
- article