Spatial immune profiling of Crohn’s disease fistula carcinomas—defining a distinct cancer subtype
The immune landscape of CD-associated Fi-Cas exhibits features of both CD fistulas and CRC, suggesting a complex pathogenesis influenced by chronic inflammation. Our data suggest that Fi-Cas represent a unique cancer subtype, that requires further analysis to develop targeted therapeutic strategies.
Authors
- Christoph Treese (ORCID: https://orcid.org/0000-0001-9120-6773)
- Alexander Arnold (ORCID: https://orcid.org/0000-0002-7727-0688)
- Daniela Paclik (ORCID: https://orcid.org/0000-0003-2791-3136)
- Britta Siegmund (ORCID: https://orcid.org/0000-0002-0055-958X)
- Adrian Huck (ORCID: https://orcid.org/0000-0003-1151-3891)
- Adrian Huck
- Michael Vieth
- Clemens Kurth-Stavenhagen
Institutions
- Bayreuth Medical Center (DE)
- Humboldt-Universität zu Berlin (DE)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf086
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00