[Spermine suppresses GBP5-mediated NLRP3 inflammasome activation in macrophages to relieve vital organ injuries in neonatal mice with enterovirus 71 infection].
Spermine suppressed EV71 infection-induced inflammatory responses by inhibiting GBP5-mediated NLRP3 inflammasome activation, suggesting a new strategy for treatment of severe HFMD.
Authors
- Zhihua Tian (ORCID: https://orcid.org/0009-0008-2117-7514)
- Hong Cao (ORCID: https://orcid.org/0000-0002-8574-6420)
- Fangfang Zhang (ORCID: https://orcid.org/0000-0002-6437-6096)
- Xin Chen (ORCID: https://orcid.org/0000-0002-2628-4027)
- Qingqing Yang (ORCID: https://orcid.org/0000-0002-7560-295X)
- Baimao Zhong
Institutions
- Southern Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-05-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.05.02
- Primary Topic
- Pediatric health and respiratory diseases
- Type
- article