Macrophage-Derived Exosomal MALAT1 Regulates Autophagy through miR-204-5p/ATG7 Axis in H9C2 Cardiomyocytes and Diabetic Rat Heart.
In conclusion, we discovered that exosomal MALAT1 derived from macrophages after high glucose treatment could sequester miR-204-5p, leading to the upregulation of ATG7 expression, and this was linked to the regulation of autophagy in H9C2 cardiomyocytes and streptozotocin-induced diabetic hearts.
Authors
- Wei‐Jen Fang
- Chun-Ming Pan
- Kou‐Gi Shyu (ORCID: https://orcid.org/0000-0002-6620-5661)
- Wang Baowei (ORCID: https://orcid.org/0000-0003-4367-2248)
Publication Details
- Journal
- PubMed
- Published
- 2025-05-01
- DOI
- https://doi.org/10.6515/acs.202505_41(3).20250224d
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00