Multiplex LC–MS/MS assay for simultaneous quantification of artesunate and its active metabolite dihydroartemisinin with pyronaridine, proguanil, cycloguanil, and clindamycin in pharmacokinetic studies
The developed assay can support the further clinical development of these TACTs and MDACTs, ultimately contributing to enhanced malaria treatment strategies.
Authors
- Michael Ramharter (ORCID: https://orcid.org/0000-0002-9259-1885)
- Christoph Pfaffendorf
- Jean Claude Dejon‐Agobé (ORCID: https://orcid.org/0000-0003-3816-998X)
- Johannes Mischlinger (ORCID: https://orcid.org/0000-0002-2012-6327)
- Sebastian G. Wicha (ORCID: https://orcid.org/0000-0002-8773-4845)
- Oumou Maïga‐Ascofaré (ORCID: https://orcid.org/0000-0003-2947-5651)
- Ayôla Akim Adégnika (ORCID: https://orcid.org/0000-0003-3197-5946)
- Ebenezer Ahenkan
Institutions
- Universität Hamburg (DE)
- Kwame Nkrumah University of Science and Technology (GH)
- Centre de Recherche Médicales de Lambaréné (GA)
- University Medical Center Hamburg-Eppendorf (DE)
- German Center for Infection Research (DE)
- Kumasi Centre for Collaborative Research in Tropical Medicine (GH)
- University of Tübingen (DE)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1186/s12936-025-05387-6
- Citations
- 2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Deutsches Zentrum für Infektionsforschung
- Universität Hamburg