Gleason score down and upgrading at radical prostatectomy in targeted vs. systematic prostate biopsy: Findings from an institutional cohort
Our study highlights potential downgrading risk associated with TPBx alone, particularly in patients with initial GS of 4 + 4/GG4. While this has minimal implications for high-risk PCa, it raises concerns about potential overdiagnosis and overtreatment in men eligible for active surveillance (AS) who may be downgraded from intermediate-risk to low-risk or favourable intermediate-risk categories. This underscores the importance of using both TPBx and SPBx for PCa diagnosis and risk assessment.
Authors
- Pietro Pepe (ORCID: https://orcid.org/0000-0002-8375-4419)
- Ludovica Pepe
- Valeria Zuccalà (ORCID: https://orcid.org/0000-0003-3478-9217)
- Maurizio Martini (ORCID: https://orcid.org/0000-0002-6260-6310)
- Mara Curduman
- Antonio Ieni (ORCID: https://orcid.org/0000-0003-2878-3572)
- Vincenzo Fiorentino (ORCID: https://orcid.org/0000-0002-1132-1761)
- Cristina Pizzimenti (ORCID: https://orcid.org/0000-0002-4387-7174)
Institutions
- University of Messina (IT)
- Ospedale Cannizzaro (IT)
- Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte (IT)
Publication Details
- Journal
- Pathology - Research and Practice
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1016/j.prp.2025.156040
- Citations
- 7
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 10.63