<scp>SPARC</scp> Promotes Aerobic Glycolysis and 5‐Fluorouracil Resistance in Colorectal Cancer Through the <scp>STAT3</scp>/<scp>HK2</scp> Axis
Our results confirmed that SPARC affects the chemoresistance of CRC to 5-FU through the STAT3/HK2 axis and is one of the indispensable factors affecting the development of 5-FU resistance in CRC.
Authors
- Kanger Shen
- Jingrong Xiang
- Qinhua Xi (ORCID: https://orcid.org/0000-0002-0629-7867)
- Kexi Yang
- Tongguo Shi (ORCID: https://orcid.org/0000-0002-5382-2775)
- Huan Zhang (ORCID: https://orcid.org/0000-0002-2289-7707)
- Jie Feng (ORCID: https://orcid.org/0009-0006-2203-2750)
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1002/cam4.70972
- Citations
- 4
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.67