Promoter hypermethylation of SFRP1 is an allele fraction-dependent prognostic biomarker in metastatic pancreatic ductal adenocarcinoma
Patients with phSFRP1<sup>high</sup> had significantly shorter survival than phSFRP1<sup>low</sup> or umSFRP1, indicating AF-dependent prognostic effects. phSFRP1<sup>low</sup> had a worse prognosis than umSFRP1 at only 12 months, indicating dynamic changes. This could help personalize the treatment of PDAC.
Authors
- Stine Dam Henriksen (ORCID: https://orcid.org/0000-0003-0286-397X)
- Louise S. Rasmussen (ORCID: https://orcid.org/0000-0002-6042-779X)
- Inge Søkilde Pedersen (ORCID: https://orcid.org/0000-0002-9902-8040)
- Malene Pontoppidan Stoico
- Anders Christian Larsen (ORCID: https://orcid.org/0000-0003-2489-0848)
- Carsten Palnæs Hansen (ORCID: https://orcid.org/0000-0002-9256-2240)
- Lars Henrik Jensen (ORCID: https://orcid.org/0000-0002-0020-1537)
- Søren Lundbye‐Christensen (ORCID: https://orcid.org/0000-0002-9420-2783)
- Henrik Krarup (ORCID: https://orcid.org/0000-0001-5294-2428)
- Julia S. Johansen (ORCID: https://orcid.org/0000-0002-4217-6560)
- Per Pfeiffer (ORCID: https://orcid.org/0000-0002-2925-0586)
- Inna Markovna Chen (ORCID: https://orcid.org/0000-0003-2891-0762)
- Benjamin Emil Stubbe (ORCID: https://orcid.org/0000-0002-2727-5915)
- Jane Preuss Hasselby (ORCID: https://orcid.org/0000-0001-9153-0100)
- Ole Thorlacius‐Ussing (ORCID: https://orcid.org/0000-0003-4963-1551)
- Simone Karlsson Terp (ORCID: https://orcid.org/0000-0003-2635-3667)
- Laurids Østergaard Poulsen (ORCID: https://orcid.org/0000-0002-0466-976X)
- Mehmet Birhan Yılmaz (ORCID: https://orcid.org/0000-0002-8169-8628)
- Torben Hansen (ORCID: https://orcid.org/0000-0001-8748-3831)
- Poul Henning Madsen
- Astrid Z. Johansen
Institutions
- University of Copenhagen (DK)
- Aalborg University Hospital (DK)
- Odense University Hospital (DK)
- Herlev Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Region of Southern Denmark (DK)
- Aalborg University (DK)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3389/fonc.2025.1568386
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Aalborg Universitet
- Aalborg Universitetshospital