Developing an in vitro osteochondral micro-physiological system for modeling cartilage-bone crosstalk in arthritis
This model can be used to further probe the crosstalk between bone and cartilage in arthritis, allowing researchers to tease out the effect of specific inflammatory agents or therapeutics <i>in vitro</i>.
Authors
- Kyra W.Y. Smith (ORCID: https://orcid.org/0000-0002-2878-8616)
- Irene Chiesa (ORCID: https://orcid.org/0000-0002-1260-4990)
- Hao Wu (ORCID: https://orcid.org/0000-0003-2089-530X)
- Giovanni Vozzi (ORCID: https://orcid.org/0000-0002-9414-9994)
- Carmelo De Maria (ORCID: https://orcid.org/0000-0002-1368-3571)
- Riccardo Gottardi (ORCID: https://orcid.org/0000-0001-8040-5531)
- Stephanie Fung (ORCID: https://orcid.org/0000-0002-2177-4254)
Institutions
- University of Pisa (IT)
- Piaggio (Italy) (IT)
- Children's Hospital of Philadelphia (US)
- Ri.MED (IT)
- University of Pennsylvania (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1495613
- Citations
- 5
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- University of Pennsylvania
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases