7-Hydroxyflavone Mitigates Osteoporosis Via Key Signaling Pathways in a Dexamethasone-induced Rat Model
The study data confirmed that concurrent treatment of 7HF showed evident effects in the protection against dexamethasone-induced osteoporosis through the modulation of the GATA- 3/Caspase-3/NF-KB pathway. Collectively, the ADMET analysis suggests that 7HF possesses promising pharmacokinetic and toxicological attributes, making it a viable candidate for drug development.
Authors
- K. Sanjana P. Devi (ORCID: https://orcid.org/0000-0002-1788-731X)
- V. Ravichandiran (ORCID: https://orcid.org/0000-0001-7820-9486)
- Thukani Sathanantham Shanmugarajan
Institutions
- Vels University (IN)
- Delhi Pharmaceutical Science and Research University (IN)
Publication Details
- Journal
- Current Topics in Medicinal Chemistry
- Published
- 2025-05-26
- DOI
- https://doi.org/10.2174/0115680266387622250519052501
- Citations
- 2
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61