A Novel Weight Loss Mechanism of Hydroxysafflor Yellow A in Obese Mice: Involvement of Immune Inflammation via Prkcd, Btk, and Vav1 Genes in Adipose Tissue
HSYA demonstrates the therapeutic potential for obesity by modulating immuneinflammatory pathways in WAT, specifically targeting Prkcd, Btk, and Vav1 in mice. Given its clinical use in cardiovascular disease, these findings suggest that HSYA may offer broader therapeutic benefits, including obesity management, though further studies are needed to clarify the mechanisms and assess its applicability to humans.
Authors
- Xiaorui Lyu (ORCID: https://orcid.org/0000-0002-6523-4292)
- Hongbo Yang (ORCID: https://orcid.org/0000-0003-1694-9352)
- Fengying Gong (ORCID: https://orcid.org/0000-0002-6361-3811)
- Yuchen Jiang (ORCID: https://orcid.org/0000-0003-0968-2012)
- Wenjing Hu (ORCID: https://orcid.org/0000-0002-8927-2445)
- Hui Pan (ORCID: https://orcid.org/0000-0003-2413-0646)
- Xiaonan Guo
- Linjie Wang (ORCID: https://orcid.org/0000-0002-9548-0398)
- Yuxing Zhao
- Huijuan Zhu (ORCID: https://orcid.org/0000-0002-8045-6539)
- Ruizhen Hou
- Kemin Yan
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Current Pharmaceutical Biotechnology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.2174/0113892010375949250519062337
- Primary Topic
- Sunflower and Safflower Cultivation
- Type
- article
- Field-Weighted Citation Impact
- 0.00