Preoperative Radiotherapy in Patients With Localized Ewing Sarcoma Enrolled on AEWS1031: A Report From the Children's Oncology Group
Patients with resectable Ewing sarcoma (ES) in select sites, such as the pelvis or chest wall, have a higher risk of positive microscopic margins following surgery. AEWS1031 was the first North American/Australasia ES cooperative group trial allowing standardized preoperative radiotherapy, intended to minimize the morbidity of combined modality local tumor control as well as improve the likelihood of clear surgical margins. In this study, we found that the use of low-dose preoperative radiation to a smaller target volume resulted in a high rate of R0 resection. The robust pathologic response rate strengthens existing evidence illustrating the radiosensitivity of Ewing sarcoma.
Authors
- Steven G. DuBois (ORCID: https://orcid.org/0000-0003-0882-738X)
- Safia K. Ahmed (ORCID: https://orcid.org/0000-0003-2482-594X)
- Paul J. Chuba (ORCID: https://orcid.org/0000-0002-4423-3899)
- Helen Nadel (ORCID: https://orcid.org/0000-0003-0236-7298)
- Patrick J. Leavey (ORCID: https://orcid.org/0000-0002-0541-2536)
- Damon R. Reed (ORCID: https://orcid.org/0000-0002-8238-2465)
- Richard Görlick (ORCID: https://orcid.org/0000-0001-8995-2929)
- Alexander B. Christ (ORCID: https://orcid.org/0000-0002-0447-5762)
- Natalie DelRocco (ORCID: https://orcid.org/0000-0002-8139-9839)
- Katherine A. Janeway (ORCID: https://orcid.org/0000-0001-6000-3594)
- Daniel J. Indelicato (ORCID: https://orcid.org/0000-0001-5765-1873)
- Alexandra K. Callan (ORCID: https://orcid.org/0000-0002-2680-0554)
- Odion T. Binitie (ORCID: https://orcid.org/0000-0002-2674-9939)
- Bruce Pawel (ORCID: https://orcid.org/0000-0001-7678-5324)
- Nadia N. Laack (ORCID: https://orcid.org/0000-0002-4385-6349)
- Leo Mascarenhas (ORCID: https://orcid.org/0000-0001-7790-0777)
- Mark Krailo (ORCID: https://orcid.org/0000-0002-7608-0698)
- Allen Buxton
- Sandy Kessell
Institutions
- University of Southern California (US)
- Cedars-Sinai Medical Center (US)
- Ascension (US)
- Mayo Clinic (US)
- Children's Hospital of Los Angeles (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of California, Los Angeles (US)
- WinnMed (US)
- Webber International University (US)
- Moffitt Cancer Center (US)
- University of Florida (US)
- Children's Oncology Group (US)
- Stanford Medicine (US)
- Mayo Clinic in Florida (US)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- The University of Texas Southwestern Medical Center (US)
- Florida College (US)
- Stanford University (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1002/pbc.31820
- Citations
- 2
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- St. Baldrick's Foundation
- National Institutes of Health
- National Cancer Institute