GSDMD is a novel predictive biomarker for immunotherapy response: in the pan-cancer and single cell landscapes
Our findings highlight GSDMD as a potential biomarker for predicting immunotherapy response and as a modulator of tumor-immune interactions. These results provide a foundation for future studies exploring GSDMD-targeted strategies to enhance immunotherapeutic efficacy.
Authors
- Shi Zhan (ORCID: https://orcid.org/0000-0002-5023-6789)
- Li Huang (ORCID: https://orcid.org/0000-0001-7389-1105)
- Jinbao Xiang (ORCID: https://orcid.org/0000-0002-2628-3075)
- Ming Liu (ORCID: https://orcid.org/0000-0002-8662-3190)
- Feng Chen (ORCID: https://orcid.org/0000-0002-2699-7190)
- Qin Zhang (ORCID: https://orcid.org/0000-0001-8243-6905)
- Lin Chen (ORCID: https://orcid.org/0000-0003-2354-3182)
- Ye Yang (ORCID: https://orcid.org/0000-0003-0934-2747)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1570901
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China