Multidimensional Evidence Chain of Nutritional Impact on Digestive System Tumors: Integration of Mendelian Randomization Causal Inference, NHANES Epidemiological Data, and Transcriptomic Analysis
This study systematically reveals multidimensional mechanisms linking malnutrition to digestive system tumor progression <i>via</i> genetic, molecular, and immune pathways. Key genes (ACTG2, MSX1, COL7A1) and gender-specific interventions offer novel strategies for precision oncology. Future validation in cross-ethnic cohorts and clinical trials is warranted.
Authors
- Yan Yang
- Chunlei Miao
- Rong Fu
- Xueyan Jiang (ORCID: https://orcid.org/0000-0002-5231-2677)
- Yaodong Ping
- Yuan Chen
- Hong Liu (ORCID: https://orcid.org/0000-0001-6040-5323)
- Yu‐Li Liu (ORCID: https://orcid.org/0000-0001-7519-2965)
- Benben Zhu
- Yiwei Hao
Institutions
- Mongolian National University of Medical Sciences (MN)
- Ministry of Education (ET)
Publication Details
- Journal
- Nutrition and Cancer
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1080/01635581.2025.2508532
- Citations
- 2
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.94