Trimethylamine N-oxide Impairs Oocyte Maturation and Embryogenesis via NF-κB/NLRP3 Pathway Modulation

Findings demonstrate that TMAO disrupts oocyte development through NF- κB/NLRP3 activation, contributing to ovarian dysfunction. Notably, targeting TMAO and its downstream signaling could serve as a novel therapeutic strategy for premature ovarian insufficiency (POI).

Authors

Yanle Guo (ORCID: https://orcid.org/0000-0003-0134-377X)
Jiwu Lou (ORCID: https://orcid.org/0000-0001-8250-1498)
Yong-Mei Zhang (ORCID: https://orcid.org/0000-0002-8289-2107)
Fengping He
Tizhen Yan

Institutions

Shantou University (CN)
Yue Bei People's Hospital (CN)

Publication Details

Journal: Current Cancer Drug Targets
Published: 2025-05-26
DOI: https://doi.org/10.2174/0115680096364675250419135908
Primary Topic: Reproductive System and Pregnancy
Type: article
Field-Weighted Citation Impact: 0.00

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article

Trimethylamine N-oxide Impairs Oocyte Maturation and Embryogenesis via NF-κB/NLRP3 Pathway Modulation

Yanle Guo, Jiwu Lou, Yong-Mei Zhang, Fengping He et al.

May 26, 2025

Current Cancer Drug Targets

Reproductive System and Pregnancy

article

Trimethylamine N-oxide Impairs Oocyte Maturation and Embryogenesis via NF-κB/NLRP3 Pathway Modulation

Yanle Guo, Jiwu Lou, Yong-Mei Zhang, Fengping He, Tizhen Yan

May 26, 2025article en

Abstract

Findings demonstrate that TMAO disrupts oocyte development through NF- κB/NLRP3 activation, contributing to ovarian dysfunction. Notably, targeting TMAO and its downstream signaling could serve as a novel therapeutic strategy for premature ovarian insufficiency (POI).

Current Cancer Drug TargetsVol. 26(1)

Shantou University (CN), Yue Bei People's Hospital (CN)

Good health and well-being

Openalex Percentile: Top 87%

Reproductive System and Pregnancy

DOI Source OpenAlex

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