Revealing the effects of the cell cycle on cellular uptake of nano-drugs at single particle level
We analyzed the dynamic parameters for nano-drug entry into cells in different stages of the cell cycle, verifying the effects of stiffness and membrane receptor expression level. The cell cycle synchronization inhibitor and cell line were also considered. This report will provide insights into the enhancement of cell entry efficiency of nano-drugs by regulating the cell cycle.
Authors
- Jiahui Zhang (ORCID: https://orcid.org/0000-0002-6895-8069)
- Xiaoping Song (ORCID: https://orcid.org/0000-0002-0436-1757)
- Hui Wang (ORCID: https://orcid.org/0000-0003-1094-8826)
- Siying Li (ORCID: https://orcid.org/0000-0001-9483-5428)
- Yuping Shan (ORCID: https://orcid.org/0000-0002-1718-4067)
Institutions
- Changchun University of Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01516b
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China