Sequential nanoparticle therapy targeting neutrophil hyperactivation to prevent neutrophil-induced pulmonary fibrosis
These findings highlight the efficacy of DNase-I@PDA NPs and Siv@PLGA NPs in addressing both acute inflammation and chronic fibrosis by simultaneously targeting NET formation and neutrophil hyperactivation. This dual nanoparticle therapy represents a promising clinical strategy for treating COVID-19-associated pulmonary complications, including PASC, by preventing long-term fibrotic progression and promoting lung recovery.
Authors
- Kyung Soo Hong (ORCID: https://orcid.org/0000-0003-2931-6861)
- Chun Gwon Park (ORCID: https://orcid.org/0000-0002-8926-3418)
- Juwon Park (ORCID: https://orcid.org/0000-0002-9873-0137)
- June Hong Ahn (ORCID: https://orcid.org/0000-0001-7104-8325)
- Wonhwa Lee
- Jungbum Kim (ORCID: https://orcid.org/0009-0008-4043-7983)
- Hong Sook Kim (ORCID: https://orcid.org/0000-0003-0971-0853)
- Ha Eun Shin
- Wooram Park (ORCID: https://orcid.org/0000-0002-4614-0530)
- Na Kyeong Lee (ORCID: https://orcid.org/0000-0002-6461-4445)
- Hye-Jin Lee (ORCID: https://orcid.org/0000-0002-3535-965X)
- Jisun Kim (ORCID: https://orcid.org/0000-0001-9250-5353)
- Jongsu Kim (ORCID: https://orcid.org/0000-0001-8390-0570)
- Se−Na Kim (ORCID: https://orcid.org/0009-0003-9750-2639)
- Donghyuk Seo
Institutions
- Chungbuk National University (KR)
- Seowon University (KR)
- Yeungnam University Medical Center (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s12951-025-03421-y
- Citations
- 5
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea