Longitudinal Evaluation of Immunological Biomarkers in Previously Untreated/Minimally Treated Patients With Severe and Moderately Severe Haemophilia A During Exposure to Factor VIII: Results From the HEMFIL Study
Patients who failed ITI had higher concentration of IL-2, IL-10, TNF, INF-γ and CCL5 in comparison with complete responders, suggesting that these biomarkers could be potential predictors of ITI outcome.
Authors
- Claúdia Santos Lorenzato (ORCID: https://orcid.org/0000-0001-6662-4623)
- M. Cerqueira (ORCID: https://orcid.org/0000-0001-6681-8911)
- Vivian Karla Brognoli Franco (ORCID: https://orcid.org/0000-0002-0297-1455)
- Luciana W. Zuccherato (ORCID: https://orcid.org/0000-0002-0860-6571)
- Renan P. Souza (ORCID: https://orcid.org/0000-0002-9479-4432)
- Letícia Lemos Jardim (ORCID: https://orcid.org/0000-0003-3358-0075)
- Márcio Antônio Portugal Santana (ORCID: https://orcid.org/0009-0001-0658-951X)
- B. Santos (ORCID: https://orcid.org/0000-0002-3372-3390)
- Daniel Gonçalves Chaves (ORCID: https://orcid.org/0000-0001-7431-3884)
- Suely Meireles Rezende (ORCID: https://orcid.org/0000-0002-3083-7093)
Institutions
- Universidade Federal de Minas Gerais (BR)
- Instituto Federal de Educação, Ciência e Tecnologia de Minas Gerais (BR)
- Hemorio (BR)
- Faculdade de Ciências Médicas de Minas Gerais (BR)
- Fundação Hemopa (BR)
- Fundação Centro de Hematologia e Hemoterapia de Minas Gerais (BR)
Publication Details
- Journal
- Haemophilia
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1111/hae.70048
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior