Impact of <scp>NA</scp>‐1 on Pericyte‐Driven Vasoconstriction and Its Role in No‐Reflow During Cerebral Ischemia–Reperfusion
NA-1 inhibits pericyte constriction following ischemia-reperfusion by reducing ET-1 levels. It improves capillary no-reflow in mice, enhances cerebral perfusion, decreases infarct size, and mitigates behavioral deficits.
Authors
- Ximing Nie (ORCID: https://orcid.org/0000-0002-8380-4076)
- Zheng Wei (ORCID: https://orcid.org/0000-0001-7682-9286)
- Lina Zheng (ORCID: https://orcid.org/0000-0003-1501-0351)
- Yuchuan Ding (ORCID: https://orcid.org/0000-0001-5358-1660)
- Xinxuan Yang (ORCID: https://orcid.org/0009-0000-9174-5881)
- Xin Liu (ORCID: https://orcid.org/0000-0003-2756-4976)
- Liping Liu (ORCID: https://orcid.org/0000-0003-2943-055X)
- Hao Tian (ORCID: https://orcid.org/0000-0001-7128-7545)
- Jiahui Zhao (ORCID: https://orcid.org/0000-0003-3271-4334)
Institutions
- Capital Medical University (CN)
- Wayne State University (US)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1111/cns.70409
- Citations
- 3
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- National Natural Science Foundation of China