The P53N236S Mutation Plays a Regulatory Role in Osteosarcoma Metastasis Via the Cholesterol-Hedgehog Pathway
In summary, we confirmed the enhanced metastatic ability of p53S sarcoma primary cells via <i>in vivo</i> and <i>in vitro</i> experiments and preliminarily confirmed the mechanism by which p53S promotes cholesterol synthesis and further activates the HH signaling pathway, thus leading to sarcoma metastasis. This study provides a theoretical basis for further revealing the function and mode of action of p53 mutations in the process of sarcoma metastasis, thereby providing a new potential target for the targeted diagnosis and treatment of sarcoma.
Authors
- Juhua Dan
- Lulin Wang (ORCID: https://orcid.org/0000-0001-7814-3245)
- Zhang Shuojie
- Jiawei Liu (ORCID: https://orcid.org/0000-0003-1789-9430)
- Xie Xiaoli
- Hui Wang (ORCID: https://orcid.org/0000-0003-4330-2511)
- Jing Jia (ORCID: https://orcid.org/0000-0002-2275-4239)
Institutions
- Kunming University (CN)
- Kunming Medical University (CN)
Publication Details
- Journal
- Cellular Physiology and Biochemistry
- Published
- 2025-05-26
- DOI
- https://doi.org/10.33594/000000780
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Kunming University of Science and Technology
- Guizhou Medical University
- National Institutes of Health
- Applied Basic Research Foundation of Yunnan Province