CD248 deficiency promotes angiotensin II‐induced aortic lesion by attenuating receptor stability in smooth muscle cells
CD248 reduces the occurrence of angiotensin II (Ang II)-induced aortic lesion by facilitating collagen production to provide load-bearing properties to the aortic wall. CD248 regulates the stability of the membrane receptors for Ang II and PDGF in VSMCs. The C-terminal cytoplasmic tail of CD248 is a crucial domain that potentially regulates the stability of Ang II and PDGF receptors. This knowledge can enhance our understanding of how abdominal aortic aneurysm (AAA) can be treated through CD248-mediated signaling to maintain aortic wall strength during the remodeling process.
Authors
- Chang‐Hsiao Chen (ORCID: https://orcid.org/0000-0002-1310-0954)
- Pei‐Jane Tsai (ORCID: https://orcid.org/0000-0001-9938-3299)
- Shu‐Wha Lin (ORCID: https://orcid.org/0000-0001-6748-5581)
- Hua‐Lin Wu (ORCID: https://orcid.org/0000-0001-5069-4854)
- Tai‐Tzu Hsieh
- Cheng‐Hsiang Kuo (ORCID: https://orcid.org/0000-0002-4885-9020)
- Ya‐Chu Ku
- Chien‐Hung Yu (ORCID: https://orcid.org/0000-0003-0337-4473)
- Yau‐Sheng Tsai (ORCID: https://orcid.org/0000-0002-5560-2661)
- Bi‐Ing Chang
- Yi‐Heng Li (ORCID: https://orcid.org/0000-0003-0390-2360)
- Chwan‐Yau Luo
Institutions
- Kaohsiung Medical University (TW)
- National Taiwan University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/ctm2.70352
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Health Research Institutes
- Kaohsiung Medical University Chung-Ho Memorial Hospital