Intestinal inflammation disrupts energy metabolism in layer pullets: insights into energy partitioning and intestinal metabolomic profiling
Immune stimulation by DSS induced a negative energy balance in layer pullets, characterized by reduced AME intake (-190.47 kJ/kg BW<sup>0.75</sup>) and compromised RE (-18.81% of AME intake). Disruption of intestinal energy profiling was observed in inflammation-challenged pullets, such as accumulation of α-KG and ATP, reduced NAD<sup>+</sup> and amino acids, which could provide valuable insights for developing effective intervention strategies.
Authors
- Lihua Zhao (ORCID: https://orcid.org/0000-0002-1758-9873)
- Bei Huang
- Zhibin Ban (ORCID: https://orcid.org/0000-0003-0786-8999)
- Bingkun Zhang (ORCID: https://orcid.org/0000-0002-5088-687X)
- Simiao Chen (ORCID: https://orcid.org/0000-0003-0555-2157)
- Qiuyu Jiang (ORCID: https://orcid.org/0000-0003-4461-2829)
Institutions
- Jilin Academy of Agricultural Sciences (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s40104-025-01204-x
- Citations
- 2
- Primary Topic
- Animal Nutrition and Physiology
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- China Agricultural University
- Jilin Academy of Agricultural Sciences